Đảng Cộng sản Việt Nam lãnh đạo hoạt động đối ngoại nhân dân từ năm 1991 đến năm 2010
http://repository.vnu.edu.vn/handle/VNU_123/19945
Điều chế và kiểm tra chất lượng kháng thể đơn dòng gắn đồng vị phóng xạ I-rituximab dùng trong điều trị U Lympho ác tính không Hodgkin
Monoclonal antibody rituximab labeled with 131 I was used in the treatment of B cell non Hodgkin’s Lymphoma in targeted therapy. The radioiodinated rituximab was prepared using chloramin T and iodogen methods. The radioimmunoconjugated quality validation was performed using chemical tests such as fast protein liquid chromatography, radioautography, thin layer chromatography, paper chromatography and photon gamma ray spectrum. Biological evaluations of this radiopharmaceutical have tested for asepsis, bacterial endotoxin, invitro stabilities and biodistribution in normal mice. Labelling yields were 95% using chloramin T and more than 85% using iodogen methods. Specific activity of labelled compound from two methods are 0.246 GBq/mg and 0.037 GBq/mg. Radiochemical purity of labeled antibody was 98% and radionuclide purity was more than 99.9%. The entry rate of radioimmunoconjugation in ...
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